The music video was filmed at Black Island Studios in London from January 30 to February 2, 2008 with Timberlake and Timbaland, directed by French duo Jonas & François (Justice's "D.A.N.C.E."), with choreography by Jamie King.
The music video begins with Timbaland performing his opening lines, in front of a screen showing exactly four minutes in the format of minutes:seconds:frames (NTSC). After some brief scenes of Madonna and Timberlake standing faced back to the camera, it shows Madonna leaning on car while pushing it back into a house where Timberlake and Madonna both sing while removing a piece of clothing as the black background follows them both, the people living in the house seem oblivious to the black background as it removes their skin and part of their flesh.
Madonna and Timberlake then jump out the window and end up in car junk yard where they begin to dance and evade the black shapes at the same time. After this they both run into a supermarket while the same black background follows them, Madonna and Timberlake begin singing in the aisle of the supermarket while shoppers carry on as normal. Madonna and Timberlake move on to start dancing on the conveyor belt at the checkouts.
They then run into a bathroom and remove another piece of clothing while the black background follows outside, they then run out of the bathroom and appear to walk in to the same room Timbaland was seen in before, they immediately start performing choreography in front of the screen, now counting down from four minutes.
They continually dance and remove a final piece of clothing from each other as the black background comes at them from both sides. The video ends with the black background finally catching up to them while they stop dancing and move closer to each other, as it starts to eat away at their skin and flesh.
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